Pregabalin, Nortriptyline HCL, and Methylcobalamin Tablets

Pregabalin, Nortriptyline HCL, and Methylcobalamin Tablets available with the branding “NU CALM” is used in combination medicine for managing neuropathic pain in the context of diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a category of progressive nerve disease that results in nerve pain attributable to nerve damage or improper functioning of the nervous system. Some include pain without stimulus, pain that is incapacitating, sharp, throbbing, stinging or stabbing, and pain by stimulus (pain results from events that are usually not painful).

Pregabalin, Nortriptyline HCL, and Methylcobalamin Tablets are a combination of three drugs: Methylcobalamin which is a vitamin, Nortriptyline an antidepressant and Pregabalin an anti-convulsant. Methylcobalamin is a vitamin that helps in the synthesis of myelin which is a protective sheath to the nerve fibers and helps in repairing damaged nerves.

Nortriptyline relieves pain by raising nerve transmitters such as serotonin and noradrenaline levels in the brain which interferes with painful signals transmitted to the brain. This works by acting upon the pain signals that are relayed in the brain and along the spinal cord to give pain relief. This together plays an effective role in the treatment of neuropathic pain.

Medical Benefits

• Methylcobalamin is a form of vitamin B that is involved in the myelination process of nerve fibres and also re-generates damaged nerve cells.
• Nortriptyline is an antidepressant that brings up the levels of nerve transmitters (serotonin and noradrenaline) in the brain that interfere with pain signals.
• Pregabalin is an anti-convulsant that works by inhibiting pain signals that pass through the brain and spinal cord.
• It is used for the treatment of neuropathic pain related to diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc.
• Together, they assist in the management of neuropathic pain.

Directions For Use

• Swallow Pregabalin, Nortriptyline HCL, and Methylcobalamin Tablets exactly as your doctor advised it to be used.
• It should be consumed with meals to avoid any abnormalities in the stomach.
• Take it with water and should not be chewed or crushed.
• Make sure the medication is out of reach of children.

Storage

• Do not expose the medicine to heat or sunlight.
• Protect it from a dry cool place.
• Make sure that the lid is properly closed to protect the components of the ingredients.
• Store Pregabalin, Nortriptyline HCL, and Methylcobalamin Tablets away from children’s and pets’ reach.

Precautions

• Consult a doctor before its intake as it may interact with anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), and sedative-hypnotics medications (e.g. zolpidem).
• Avoid alcohol consumption while taking this medicine as it might cause increased drowsiness and sleepiness.
• Use this medicine after medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, schizophrenia, thyroid disorders and urinary retention.
• This medicine may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

Side Effects

• Headache
• Constipation
• Dry mouth
• Diarrhoea
• Feeling sleepy, tired or dizzy

Frequently Asked Questions (FAQs)

What can be done to overcome dry mouth?

Dry mouth is likely to be suffered by anyone who uses this medicine. To avoid this, minimize caffeine, refrain from smoking and using mouthwash that contains alcohol, drink plenty of water, and use sugarless gum or candies to increase saliva.

Can I discontinue this medicine in case I feel better?

Methylcobalamin, Nortriptyline, and Pregabalin should not be stopped without consulting the doctor. If the person suddenly decides to quit, the withdrawal symptoms will develop. Always continue to take the medicine in the right amount as recommended by the doctor. If you have any concerns or issues, you should consult your doctor.

Does this composition work for Diabetic Neuropathy? 

Yes, this combination is used to treat diabetic neuropathy, which is nerve damage as a result of high blood sugar levels, it mainly affects the legs and feet.

Can this medicine lead to oedema?

It can also cause side effects such as peripheral oedema which is the swelling of the hands and lower legs. To prevent this avoid staying for long periods either seated or standing and instead of this, try to lie down with a pillow placed under the legs.